Glucose tolerance, insulin sensitivity and beta-cell function in patients with rheumatoid arthritis treated with or without low-to-medium dose glucocorticoids
GC-using and GC-naive patients with RA had comparable metabolic parameters, and had decreased insulin sensitivity and beta-cell function as compared with healthy controls. Although cumulative GC dose was shown to have a negative impact on glucose tolerance state and insulin sensitivity, confounding by indication remains the main challenge in this cross-sectional analysis.
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Authors: Hoes, J. N.; van der Goes, M. C.; van Raalte, D. H.; van der Zijl, N. J.; den Uyl, D.; Lems, W. F.; Lafeber, F. P.; Jacobs, J. W.; Welsing, P. M.; Diamant, M.; Bijlsma, J. W. Title: Glucose tolerance, insulin sensitivity and beta-cell function in patients with rheumatoid arthritis treated with or without low-to-medium dose glucocorticoids Year: 2011 Journal: Ann Rheum Dis Volume: 70 Issue: 11 Pages: 1887-94 Pubmed Link: Click here. |